Le syndrome associe

• Myopathie mitochondriale

• Encéphalopathie

• Acidose Lactique

• tableaux neurologiques aigus Stroke-like

CT
General features include

• multiple infarcts
• involving multiple vascular territories
• symmetrical or asymmetrical 
• parieto-occipital and parieto-temporal most common
• basal ganglial calcification
• more prominent feature in older patients
• atrophy

• chronic infarcts
• involving multiple vascular territories
• symmetrical or asymmetrical 
• parieto-occipital and parieto-temporal most common
• acute infarcts
• swollen gyri with increased T2 signal
• may enhance
• subcortical white matter involved
• increased DWI with little if any change on ADC: thought to represent vasogenic rather than cytotoxic oedema

pronostic sévère. Chaque épisode peut entraîner le décès du patient.